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Endocannabinoids System

What are Endocannabinoids?

In 1992, at the Hebrew University in Jerusalem, two doctors (Dr. Lumir Hanus and Dr. William Devane) while researching THC discovered receptors called endocannabinoids. This signaling system is involved in regulating a range of biological functions. These receptors (CB1 and CB2) are sites for CBD within your body and brain. Endocannabinoids can operate like neurotransmitters, similar to dopamine or serotonin, and help with regulating sleep, certain responses and pain.

Bioregulatory medicine involves the use of therapeutics to regulate these biological processes in time of illness. Natural products are one of the best ways to help the body regulate its healing process and re-establish normality.

How is the Endocannabinoid System (ECS) involved?

In 1995, researchers found that thousands of species, including humans, have receptors which work with an endocannabinoid system (ECS); playing a role in many brain and body functions.


CBD supports this system by keeping the body in balance. When an imbalance occurs, the body produces endocannabinoids that act with cannabinoid receptors. Should a deficiency occur in this system, some research suggests, that products containing cannabis may be used to reduce the deficiency.

Research of the endocannabinoid system (ECS) has linked it to regulating a variety of functions such as sleep, mood, memory, appetite, and pain. (See PubMed.Gov Endocannabinoid System: An overview of its potential in current medical practice.) It appears, the purpose of this system is to maintain a stable environment known as homeostasis within your own body. By stimulating and supporting your endocannabinoid system (ECS), it is possible to find relief for various conditions; however additional research is needed.

How does CBD interact with the endocannabinoid system (ECS)?

Current research shows that tetrahydrocannabinol (THC) interacts with your endocannabinoid system (ECS) by binding to receptors (CB1 and CB2) in the nervous system. In comparison, CBD itself does little to our ECS; however, it can activate or inhibit other compounds within this system. So, if CBD can assist our bodies from absorbing a compound that regulates pain (like anandamide), it may reduce the amount of pain you feel.

More research is needed to completely understand how CBD interacts with this system. At this time, it is known that CBD does not bind to receptors in the same way THC does since CBD does not produce a “high”.

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